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2 Thymosin Beta-4 Cardiac Repair Bock-Marquette et al., Nature (2004) This foundational paper demonstrated that the G-actin-sequestering peptide T4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes

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Semaglutide overcomes this through two structural modifications: an alanine-to-Aib substitution at position 8 (which removes the DPP-4 cleavage site) and the attachment of a C18 fatty diacid chain via a bifunctional linker at lysine position 26